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KMID : 0856920150180010051
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Journal of Hospice and Palliative Care
2015 Volume.18 No. 1 p.51 ~ p.59
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Prognostic Value of Serum Ferritin in Terminally Ill Cancer Patients
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Lee Soo-Hee
Choi Youn-Seon
Hwang In-Cheol
Yeom Chang-Hwan
Lee June-Young
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Abstract
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Purpose: Predicting life expectancy of terminally ill cancer patients is very important. In many studies, ferritinis detected at higher levels in the sera of cancer patients, and higher ferritin level correlates with aggressivenessof disease and poor outcomes of patients. This study evaluated a prognostic role of serum ferritin levels in terminallyill cancer patients.
Methods: This study enrolled 65 terminally ill cancer patients from March through June 2012. We assessed routine laboratory findings including serum ferritin levels as well as demographic and clinicalcharacteristics of the patients. To examine the association between serum ferritin levels and patient’s characteristics,we used Spearman’s correlation analysis, Wilcoxon’s rank sum test or Kruskal-Wallis test, as appropriately. Formultivariate analysis, Cox’s proportional hazard regression model was used to evaluate significance of serum ferritinlevels as a prognostic factor.
Results: A negative correlation between serum ferritin levels and survival time wasfound. After adjusting for sex, age, performance status, creatinine levels and white blood cell counts, serum ferritinlevels were significantly associated with survival time.
Conclusion: Even at the very end of life of terminal cancerpatients, serum ferritin levels were an independent prognostic factor for survival.
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KEYWORD
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Ferritins, Neoplasms, Terminally ill, Survival, Prognosis
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